Erika E. Forbes, University of Pittsburgh School of Medicine, E-731 Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15218, USA; Email: [email protected]

Conflict of interest statement: No conflicts declared.

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Abstract

Background: Although reward processing is considered an important part of affective functioning, few studies have investigated reward-related decisions or responses in young people with affective disorders. Depression is postulated to involve decreased activity in reward-related affective systems.

Methods: Using functional magnetic resonance imaging (fMRI), we examined behavioral and neural responses to reward in young people with depressive disorders using a reward decision-making task. The task involved choices about possible rewards involving varying magnitude and probability of reward. The study design allowed the separation of decision/anticipation and outcome phases of reward processing. Participants were 9–17 years old and had diagnoses of major depressive disorder (MDD), anxiety disorders, or no history of psychiatric disorder.

Results: Participants with MDD exhibited less neural response than control participants in reward-related brain areas during both phases of the task. Group differences did not appear to be a function of anxiety. Depressive and anxiety symptoms were associated with activation in reward-related brain areas.

Conclusions: Results suggest that depression involves altered reward processing and underscore the need for further investigation of relations among development, affective disorders, and reward processing.

References

Achenbach, T.M., & Edelbrock, C. (1983). Manual for the Child Behavior Checklist and Revised Child Behavior Profile. Burlington, VT: University of Vermont, Department of Psychiatry.
Beck, A.T., Ward, C.H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561–571.
Birmaher, B., Khetarpal, S., Brent, D., Cully, M., Balach, L., Kaufman, J., et al. (1997). The Screen for Child Anxiety Related Emotional Disorders (SCARED): Scale construction and psychometric characteristics. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 545–553.
Bjork, J.M., Knutson, B., Fong, G.W., Caggiano, D.M., Bennett, S.M., & Hommer, D.W. (2004). Incentive-elicited brain activation in adolescents: Similarities and differences from young adults. Journal of Neuroscience, 24, 1793–1802.
Bornert, P., Aldefeld, B., & Eggers, H. (2000). Reversed spiral MR imaging. Magnetic Resonance Medicine, 44, 479–484.
Carter, C.S., Braver, T.S., Barch, D.M., Botvinick, M.M., Noll, D., & Cohen, J.D. (1998). Anterior cingulate cortex, error detection, and the online monitoring of performance. Science, 280, 747–749.
Clark, L.A., & Watson, D. (1991). Tripartite model of anxiety and depression: Psychometric evidence and taxonomic implications. Journal of Abnormal Psychology, 100, 316–336.
Cox, R.W. (1996). AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages. Computers and Biomedical Research, 29, 162–173.
Delgado, M.R., Locke, H.M., Stenger, V.A., & Fiez, J.A. (2003). Dorsal striatum responses to reward and punishment: Effects of valence and magnitude manipulations. Cognitive, Affective, and Behavioral Neuroscience, 3, 27–38.
Drevets, W.C. (2001). Neuroimaging and neuropathological studies of depression: Implications for the cognitive-emotional features of mood disorders. Current Opinion in Neurobiology, 11, 240–249.
Elliott, R., Sahakian, B.J., Michael, A., Paykel, E.S., & Dolan, R.J. (1998). Abnormal neural response to feedback on planning and guessing tasks in patients with unipolar depression. Psychological Medicine, 28, 559–571.
Ernst, M., Nelson, E.E., Jazbec, S., McClure, E.B., Monk, C.S., Leibenluft, E., et al. (2005). Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents. NeuroImage, 25, 1279–1291.
Ernst, M., Nelson, E.E., McClure, E.B., Monk, C.S., Munson, S., Eshel, N., et al. (2004). Choice selection and reward anticipation: An fMRI study. Neuropsychologia, 42, 1585–1597.
Ernst, M., & Paulus, M.P. (2005). Neurobiology of decision making: A selective review from a neurocognitive and clinical perspective. Biological Psychiatry, 58, 597–604.
Forbes, E.E., & Dahl, R.E. (2005). Neural systems of positive affect: Relevance to understanding child and adolescent depression? Development and Psychopathology, 17, 827–850.
Forbes, E.E., Shaw, D.S., & Dahl, R.E. (in press). Alterations in reward-related decision making in boys with current and future internalizing disorders. Biological Psychiatry.
Guyer, A.E., Nelson, E.E., Perez-Edgar, K., Hardin, M.G., Roberson-Nay, R., Monk, C.S., Bjork, J.M., Henderson, H.A., Pine, D.S., Fox, N.A., & Ernst, M. (2006). Striatal functional alteration in adolescents characterized by early childhood behavioral inhibition. Journal of Neuroscience, 26, 6399–6405.
Haacke, E.M., Tkach, J.A., & Parrish, T.B. (1989). Reduction of T2* dephasing in gradient field-echo imaging. Radiology, 170, 457–462.
Hollingshead, A.B. (1975). Four factor index of social status. New Haven, CT: Yale University Sociology Department.
Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., et al. (1997). Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 980–988.
Keedwell, P.A., Andrew, C., Williams, S.C., Brammer, M.J., & Phillips, M.L. (2005a). A double dissociation of ventromedial prefrontal cortical responses to sad and happy stimuli in depressed and healthy individuals. Biological Psychiatry, 58, 495–503.
Keedwell, P.A., Andrew, C., Williams, S.C., Brammer, M.J., & Phillips, M.L. (2005b). The neural correlates of anhedonia in major depressive disorder. Biological Psychiatry, 58, 843–853.
Kerns, J.G., Cohen, J.D., MacDonald, A.W., 3rd, Cho, R.Y., Stenger, V.A., & Carter, C.S. (2004). Anterior cingulate conflict monitoring and adjustments in control. Science, 303, 1023–1026.
Kovacs, M. (1985). The children's depression inventory. Psychopharmacology Bulletin, 21, 995–998.
Lawrence, N.S., Williams, A.M., Surguladze, S., Giampietro, V., Brammer, M.J., Andrew, C., et al. (2004). Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biological Psychiatry, 55, 578–587.
Lonigan, C.J., Phillips, B.M., & Hooe, E.S. (2003). Relations of positive and negative affectivity to anxiety and depression in children: Evidence from a latent variable longitudinal study. Journal of Consulting and Clinical Psychology, 71, 465–481.
May, J.C., Delgado, M.R., Dahl, R.E., Stenger, V.A., Ryan, N.D., Fiez, J.A., et al. (2004). Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescents. Biological Psychiatry, 55, 359–366.
Mogg, K., & Bradley, B.P. (1998). A cognitive-motivational analysis of anxiety. Behaviour Research and Therapy, 36, 809–848.
Nestler, E., & Carlezon, W.A. (2006). The mesolimbic dopamine reward circuit in depression. Biological Psychiatry, 59, 1151–1159.
Noll, D.C., Cohen, J.D., Meyer, C.H., & Schneider, W. (1995). Spiral K-space MR imaging of cortical activation. Journal of Magnetic Resonance Imaging, 5, 49–56.
Rogers, R.D., Ramnani, N., Mackay, C., Wilson, J.L., Jezzard, P., Carter, C.S., et al. (2004). Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition. Biological Psychiatry, 55, 594–602.
Rogers, R.D., Tunbridge, E.M., Bhagwagar, Z., Drevets, W.C., Sahakian, B.J., & Carter, C.S. (2003). Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues. Neuropsychopharmacology, 28, 153–162.
Schultz, W. (2000). Multiple reward signals in the brain. Nature Reviews: Neuroscience, 1, 199–207.
Spear, L.P. (2000). The adolescent brain and age-related behavioral manifestations. Neuroscience and Biobehavioral Reviews, 24, 417–463.
Steinberg, L. (2004). Risk-taking in adolescence: What changes, and why? Annals of the New York Academy of Sciences, 1021, 51–58.
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., et al. (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. NeuroImage, 15, 273–289.
Vasey, M.W., & Dadds, M.R. (2001). Information-processing factors in childhood anxiety: A review and developmental perspective. In M.W. Vasey, & M.R. Dadds (Eds.), The developmental psychopathology of anxiety (pp. 253–277). New York: Oxford University.
Woods, R.P., Cherry, S.R., & Mazziotta, J.C. (1992). Rapid automated algorithm for aligning and reslicing PET images. Journal of Computer Assisted Tomography, 16, 620–633.
Woods, R.P., Mazziotta, J.C., & Cherry, S.R. (1993). MRI-PET registration with automated algorithm. Journal of Computer Assisted Tomography, 17, 536–546.

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Volume47, Issue10

November 2006

Pages 1031-1040

Reward-related decision-making in pediatric major depressive disorder: an fMRI study

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